Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects.
BACKGROUND: Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression.In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level.DICER1, an RNAse III endonuclease, is essential for the biogenesis of se